Process Development

Enabling Scalable RNA Development

Developing high-quality RNA-based therapies. Our expertise ensures scalable, phase-appropriate processes from in vitro transcription (IVT) to lipid nanoparticle (LNP) encapsulation.

Developing Scalable and High-Quality RNA Therapeutics

RNA-based therapies require precise, reproducible RNA process development to ensure high purity, potency and stability. Challenges such as low IVT yields, RNA degradation, and LNP encapsulation inefficiencies can impact clinical success and commercial scalability.

We provide integrated RNA-LNP process development, supporting clients from early-stage development through to GMP manufacturing. Our expertise covers mRNA, saRNA, cRNA, and non-viral delivery systems, ensuring an efficient and regulatory-ready pathway to commercialisation.

Our Processes

We design comprehensive RNA process development solutions, including:

Integrated RNA-LNP Workflows

Fully integrated workflows from DNA template through to fill-finish, all within the same site.

Custom Process Development

Expertise in DNA linearisation and purification, IVT optimisation, chromatography and TFF purification, lipid screening studies, encapsulation efficiency optimisation, and formulation/stability studies.

GMP-Ready Platform

A rapid, small-scale RNA process development workflow with GMP-ready RNA-LNP production, designed for direct tech transfer into GMP manufacturing at eXmoor Pharma or to an external CDMO.

Versatile RNA Production

Capable of producing mRNA, saRNA, cRNA, and other RNA-based materials for toxicology studies, analytical development, and reference standards.

Process Optimisation and Comparability Studies

Supporting process improvements through data-driven assessments, screening studies, and proof-of-concept evaluations.

Key People

Corinne McEwan

Head of RNA

Harvey Branton

Senior Translation Consultant

David Vincent

Head of Process Development

Why Partner with Us?

Complete RNA-LNP Development

Covering IVT, purification, encapsulation, and fill-finish to support clinical and commercial readiness.

Customisable Process Development

Providing both standardised and bespoke solutions, ensuring flexibility based on project needs.

Seamless GMP Integration

Expertise in technology transfer and regulatory alignment, ensuring a smooth transition into GMP manufacturing.

Integrated Analytical Support

In-house analytics for RNA integrity, encapsulation efficiency, stability testing, and product characterisation.

Optimise and Scale Your RNA Process with Confidence

From RNA process development through to GMP manufacturing, we support RNA-based therapies with integrated development and manufacturing expertise as a trusted RNA CDMO. Contact us to discuss your RNA programme.

Request a Proposal

Other Process Development Services

Cell Therapy

Our cell therapy process development team supports both autologous and allogeneic therapies, ensuring robust, scalable, and regulatory-ready processes. We have experience in iPSCs, MSCs, and immune cells, with expertise across 2D and 3D culture systems, bioreactor-based expansion, and cryopreservation strategies. Our team helps clients transition from lab-scale research to GMP manufacturing, ensuring process consistency and quality at every stage.

Vector

Developing AAV and lentivirus processes presents unique challenges in yield, purity, and scalability. Our viral vector team offers custom development programs, optimising key steps such as transfection, enrichment, and formulation. We provide scalable suspension and adherent processes, ensuring efficient vector production with a focus on cost-of-goods optimisation and regulatory compliance.